Scientist - Senior Scientist, in vivo Research CRISPR-X

Company Overview

Since its inception over a decade ago, CRISPR Therapeutics has transformed from a research-stage company advancing programs in the field of gene editing, to a company with a diverse portfolio of product candidates across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, cardiovascular and rare diseases. The Nobel Prize-winning CRISPR science has revolutionized biomedical research and represents a powerful, clinically validated approach with the potential to create a new class of potentially transformative medicines. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic partnerships with leading companies including Bayer and Vertex Pharmaceuticals. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Boston, Massachusetts and San Francisco, California, and business offices in London, United Kingdom.

Position Summary

Responsible for in vivo research design and execution across our next-generation editing modalities team, we are looking for a motivated and independent researcher/scientist with preclinical & in vivo gene therapy experience who is excited by the opportunity to develop innovative gene editing technologies. This individual will be involved in both hands-on in vivo research and strategic planning of early-stage discovery and preclinical project(s).

Opportunities in this role include designing our translational in vivo research strategy to evaluate next-gen editing technologies, ensuring appropriate resourcing for, and execution of, all preclinical in vivo studies and reports within the CRISPR-X research team, authoring preclinical content for global regulatory submissions, and providing input into senior-level governance activities and global safety reviews, as appropriate.

Responsibilities

• Lead, design, and execute research with the aims of exploring and developing next-generation gene editing strategies using CRISPR-based tools and beyond.
• Responsible for in-vivo research and execution across our next-generation modalities, covering hepatic and extra-hepatic target tissues. Lead and conduct hands-on in-vivo research and strategic planning of preclinical projects.
• Opportunities include designing translational in-vivo research strategies to evaluate novel editing modalities, ensuring appropriate resourcing for, and execution of, preclinical in-vivo editing studies as part of the CRISPR-X team, and authoring preclinical content for global regulatory submissions.
• Design, execute, and interpret research requiring in-vivo biology methods including generation, breeding, and maintenance of genetically engineered mouse models; various injection and animal surgery techniques; in-vivo assessment of biomarkers and editing outcomes; longitudinal study of animal health, disease markers, and phenotypic assays; post-mortem preparation of tissue sections, IHC, and other assays.
• Analyze and present experimental data to a wide range of audiences.
• Dissect published literature to find novel solutions to gene editing problems.
• Generate, manage, evaluate, and maintain critical data in a highly organized manner, providing statistical analysis and troubleshooting where appropriate.
• Oversees the construction and maintenance of technical databases, archives and department procedures manuals required for the CRISPR-X function.

Minimum Qualifications

• Extensive prior experience with general animal procedures, familiarity with in-vivo gene editing, including applying and developing next generation gene editing technologies, such as prime editing, base editing, and recombinases and retrotransposons, in an academic and/or industry setting, with a track record demonstrating significant contributions.
• Depending on level, degrees in Biology, Bioengineering, or related disciplines (level commensurate with experience and achievement):
  • Scientist I – PhD with 0-3 years relevant experience; non-PhD with 8-10 years progressive, relevant experience
  • Scientist II - PhD with 2-5 years relevant experience; non-PhD with 10-12 years progressive, relevant experience
  • Senior Scientist - PhD with 4-8 years relevant experience; non-PhD with 12-15 years progressive, relevant experience
• Excellent technical skills for rodent (mouse and rat) in vivo work comprising but not limited to IV injections, blood collection, necropsy.
• Experience managing multiple programs and priorities, studies, external CRO management, and budgets.
• Strong communicator and activator personality.
• Highly collaborative team player within and across multiple departments.
• Ability to manage and teach while still being hands on.

Preferred Qualifications

• Knowledge and experience in advanced in vivo techniques such as liver perfusion and hepatocyte isolation, and/or measuring lung function.
• Deep understanding of rodent (mouse and rat) in vivo techniques ranging from surgical procedures on neonates to physiological and pathological assessment of diseased adult rodents

Competencies

• Collaborative – Openness, One Team
• Undaunted – Fearless, Can-do attitude
• Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.
• Entrepreneurial Spirit – Proactive. Ownership mindset.

Due to the nature of their work, our manufacturing and lab-based positions are located fully on-site.

CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

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